Evidence-informed peptide therapy to support mitochondrial function, cellular energy, metabolic health, and healthy ageing — prescribed by Australian doctors.
As we age, cellular energy production declines, mitochondrial function deteriorates, and the biochemical signals that regulate metabolism, inflammation, and DNA repair become less efficient. These changes are measurable — and some are now addressable through targeted peptide and cofactor therapy.
The Longevity & Cellular Health program focuses on two key interventions: restoring NAD+ to youthful levels (critical for mitochondrial energy and DNA repair) and activating MOTS-C-associated metabolic pathways. Together, these target the fundamental biology of ageing rather than its symptoms.
NAD+ is a coenzyme present in every cell of the body, essential to the mitochondrial electron transport chain that produces cellular energy (ATP). It also acts as a substrate for sirtuins — longevity-associated proteins that regulate DNA repair, inflammation, and cellular stress responses.
NAD+ levels decline by approximately 50% between the ages of 40 and 60. Restoring NAD+ through subcutaneous or IV administration has been studied for improvements in energy, cognitive function, metabolic health, and cellular resilience to stress.
MOTS-C is a small peptide encoded within mitochondrial DNA — one of the first mitochondrially derived peptides identified with systemic hormonal function. It regulates metabolic homeostasis by activating AMPK (a master metabolic regulator) and folate metabolism pathways, producing effects similar to exercise and caloric restriction at the cellular level.
In animal studies, MOTS-C has been associated with improved insulin sensitivity, reduced adiposity, increased physical capacity, and extended lifespan. Human studies are emerging, but the preclinical evidence and mechanistic understanding are compelling.
NAD+ often produces the first noticeable effects — improved energy, mental clarity, and better mood within 1–2 weeks of regular administration.
MOTS-C effects on insulin sensitivity and metabolic regulation develop during this phase. Some patients notice improved body composition and exercise capacity.
The cumulative effects of improved cellular energy production, reduced oxidative stress, and enhanced metabolic signalling become more pronounced.
Longevity programs are typically ongoing with periodic dosing. Your doctor will schedule regular reviews and may recommend bloodwork to track markers.
Check your eligibility and speak with a Natura doctor about what's right for your biology.
NAD+ and MOTS-C are unregistered medicines in Australia when prescribed for longevity purposes. Prescribed under TGA prescribing authority by AHPRA-registered doctors and compounded by TGO 101-compliant pharmacists. Individual results may vary. The longevity science for MOTS-C is primarily from preclinical models — human evidence is emerging. Not suitable for patients under 18.